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• PET Brain and Whole Body Distribution Studies for Nociceptin/Orphanin FQ Peptide (NOP) Receptor Using [11C]NOP-1A.
  Interventional study. Background: - A small brain protein called nociceptin/orphanin FQ peptide (NOP) receptor may be involved in several brain diseases such as anxiety, depression, drug abuse, and seizures. Ages 18-50. Location in Bethesda, MD.

• PET Whole Body Distribution Studies Using [11C]CUMI.
  Evaluation study. Background: - Researchers studying new treatments for major depressive disorder are looking at how medications to treat depression act on the brain chemical serotonin, which interacts with specific serotonin receptors on brain cells. Ages 18-65. Location in Bethesda, MD.

• Integrated Treatment for Comorbid Depression and Obesity in Adolescents.
  Interventional study. Lifetime prevalence of major depression is estimated at 28% by age 18 (Lewinsohn et al., 1999), with higher cumulative rates in females (35%) than males (19%). Ages 12-18. Location in Providence, RI.

• Engaging Depressed Low-Income Seniors in Mental Health Services.
  Interventional study. This two-stage research study will 1. Ages 60 and over. Location in New York, NY.

• Biomarkers for Outcomes In Late-life Depression (BOLD).
  Interventional study. Major depressive disorder (MDD) is a common psychiatric illness with high cost to society and individual patients. Ages 62 and over. Location in Los Angeles, CA.

• Telephone Based Cognitive Behavioral Therapy for HIV Related Depression.
  Interventional study. The purpose of this study is to evaluate the effectiveness of a telephone-based, cognitive behavioral therapy intervention in the treatment of depression in adults diagnosed with HIV. Ages 18 and over. Location in Baltimore, MD.

• Shared Decision-Making for Elderly Depressed Primary Care Patients.
  Interventional study. Shared decision-making (SDM), in contrast to traditional medical decision-making, involves a collaborative process where patients discuss personal values and preferences and clinicians provide information to arrive at an agreed upon treatment decision. Ages 65-95. Locations in Bronx, NY; White Plains, NY.

• fMRI Study of Treatment Changes in Major Depression.
  Interventional study. The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional anti-depressants do, to find out more about the causes of depression and why people differ in the extent of problems caused by depression, and to determine if certain differences in genes within populations are related to clinical symptoms. Ages 18-50. Location in St. Louis, MO.

• Treatment for Depressed Primary Care Patients.
  Interventional study. This research study develop a collaborative depression care management model (C-DCM) that encourages collaboration between primary care physicians (PCPs) and trained social workers employed by community-based, public and nonprofit mental health clinics. Ages 60 and over. Location in White Plains, NY.

• Depression Outcomes Study of Exercise.
  Interventional study. This pilot study may yield important research findings on how to adapt exercise treatment for depression among adolescents. Ages 12-17. Location in Golden, CO.

• Using a Preparation and Education Intervention to Reduce Postpartum Depression Among New Mothers (The MADE IT 2 Study).
  Interventional study. This study will test an intervention that aims to prevent postpartum depression by providing new mothers with information on and resources for dealing with the disorder. Ages 18 and over. Location in New York, NY.

• Concurrent Treatment for Depressed Parents and DepressedAdolescents.
  Interventional study. This study will develop an integrated treatment for adolescents who are depressed and suicidal and their parents who are depressed and have a history of suicidality. Ages 12-17. Location in Providence, RI.

• Therapy Targeting Depression and HIV Treatment Adherence (The TRIAD Study).
  Interventional study. This study will test a therapy for both helping people adhere to their HIV medication regimens and treating them for depression. Ages 18 and over. Locations in Boston, MA; Providence, RI.

• Ecosystem Focused Therapy for Treating Older Depressed Stroke Survivors.
  Interventional study. This study will determine the effectiveness of a specialized psychotherapy for treating elderly stroke survivors who are depressed. Ages 50 and over. Location in White Plains, NY.

• Efficacy and Feasibility of a Personalized Treatment for Depression With Co-Occurring Anxiety.
  Interventional study. This study will examine the feasibility and efficacy of a personalized psychotherapy treatment for people with depression and co-occurring anxiety. Ages 18-65. Location in Pittsburgh, PA.

• Assessing Anterior Cingulate Brain Activity in People With Late-Life Depression.
  Evaluation study. This study will examine differences in activity of the anterior cingulate cortex, a brain area involved in emotion and cognitive regulation, between older adults with and without depression. Ages 60-85. Location in White Plains, NY.

• Personalized Indicators for Predicting Response to SSRI Treatment in Major Depression (The PRISE-MD Study).
  Interventional study. This study will examine whether measures of brain electrical signals taken after a week of antidepressant medication treatment can predict whether a full treatment regimen will be effective. Ages 21-75. Location in Los Angeles, CA.

• Using Affective Differences to Predict Response to Behavioral Treatment for Major Depressive Disorder.
  Evaluation study. This study will determine how people with depression differ from healthy people in brain activity and interpreting emotions, both before and after receiving a psychotherapy treatment. Ages 18-72. Location in Chicago, IL.

• Preventing Depression in the Children of Depressed African American Mothers.
  Interventional study. This study will test a program for preventing depression from developing in the children of depressed African American mothers. Ages 18 and over. Location in Philadelphia, PA.

• Testing the Effectiveness of Adolescent Depression Prevention Programs (The OregonBlues Study).
  Interventional study. This study will test the effectiveness of two programs for preventing depression in adolescents. Ages 13-19. Location in Eugene, OR.

• Feasibility of Telehealth Problem-Solving Therapy for Depressed Homebound Older Adults.
  Interventional study. This study will test the feasibility and effectiveness of therapy given via teleconferencing to depressed homebound older adults. Ages 50 and over. Location in Austin, TX.

• Using Cognitive Training to Improve Employment Programs for People With Severe Mental Illnesses.
  Interventional study. This study will compare the efficacy of two types of supportive treatments for a program called Individual Placement and Support, which helps people with severe mental illnesses find and keep jobs. Ages 18 and over. Location in San Diego, CA.

• Depressed Adolescents Treated With Exercise (The DATE Study).
  Interventional study. This study will evaluate whether standardized aerobic exercise is an effective treatment for depression in adolescents. Ages 12-17. Location in Dallas, TX.

• Adding an Insulin-Sensitizing Medication to Depression Treatment for People Who Are Depressed and Overweight.
  Interventional study. This study will determine whether the drug metformin improves the effects of traditional antidepressant medications in people who are overweight. Ages 20-60. Location in St. Louis, MO.

• Effectiveness of a Web-based Prevention Program for Postpartum Depression.
  Interventional study. The original trial will evaluate the effectiveness of a Web-based program in preventing postpartum depression. Ages 18-60. Location in San Francisco, CA.

• Double-Blind Placebo-Controlled Trial of Riluzole in Pediatric Bipolar Disorder.
  Interventional study. Pediatric Bipolar Disorder (BD) is uncommon in children. Ages 9-17. Location in Bethesda, MD.

• Effectiveness of Nimodipine Plus Antidepressant Medication in Treating Vascular Depression.
  Interventional study. This study will examine whether combined use of an antidepressant medication and the medication nimodipine reduces risk of depression relapse in patients with vascular depression. Ages 50 and over. Location in Pittsburgh, PA.

• Comparing Delivery Methods of Cognitive Behavioral Therapy for Depressed African-American Dementia Caregivers.
  Interventional study. This study will compare the effectiveness of face-to-face cognitive behavioral therapy versus telephone-based cognitive behavioral therapy for treating African Americans who care for family members with dementia. Ages 18 and over. Location in Tallahassee, FL.

• Incorporating Patient Treatment Choice to Improve Treatment Retention in Depressed Hispanics.
  Interventional study. This study will determine whether combination treatment driven by patient choice is better than standardized medication treatment at retaining and improving Hispanic patients with major depressive disorder. Ages 18-65. Location in New York, NY.

• Effectiveness of a Technology Assisted Behavioral Intervention in Assisting People With Major Depressive Disorder.
  Interventional study. This study will develop and evaluate the effectiveness of a technology-assisted behavioral intervention, consisting of Internet-based cognitive behavioral therapy combined with telephone and email support, in reducing depressive symptoms and improving treatment adherence in primary care patients with major depressive disorder. Ages 19 and over. Location in Chicago, IL.

• p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram.
  Evaluation study. This study will compare levels of p11 protein in people with and without major depressive disorder (MDD) and examine if p11 levels in patients are affected by treatment with citalopram (Celexa). Ages 18-65. Location in Bethesda, MD.

• Effectiveness of Emotion-Focused Cognitive Behavioral Therapy for Treating Adolescents With Emotional Disorders.
  Interventional study. This study will evaluate the effectiveness of an emotion-focused cognitive behavioral treatment program for adolescents with anxiety or unipolar depressive disorders. Ages 12-17. Location in Miami, FL.

• Sequential Treatment of Pediatric MDD to Increase Remission and Prevent Relapse.
  Interventional study. This study will compare the effectiveness of fluoxetine alone with the effectiveness of fluoxetine with cognitive behavioral therapy in increasing recovery and preventing relapse in youth with major depressive disorder. Ages 8-17. Location in Dallas, TX.

• Effectiveness of Sertraline Alone and Interpersonal Psychotherapy Alone in Treating Women With Postpartum Depression.
  Interventional study. This study will evaluate the effectiveness of antidepressant medication alone and interpersonal psychotherapy alone in treating women with postpartum depression. Ages 18-65. Locations in Iowa City, IA; Providence, RI.

• Effectiveness of Methylphenidate in Improving Cognition and Function in Older Adults With Depression.
  Interventional study. This study will evaluate the safety and effectiveness of methylphenidate in improving cognition and function in older adults with depression. Ages 60 and over. Location in Los Angeles, CA.

• Interpersonal Treatment Program to Prevent Depression and Post-Traumatic Stress Disorder in Low-Income Pregnant Women With Partner Abuse.
  Interventional study. This study will evaluate the effectiveness of an interpersonally oriented treatment program called Reach Out for a Safe Environment in preventing depression and post-traumatic stress disorder in low-income pregnant women who have experienced recent partner abuse. Ages 18-40. Location in Providence, RI.

• Depression Prevention for Pregnant Women on Public Assistance.
  Interventional study. This study will evaluate the effectiveness of an interpersonal therapy treatment called the Postpartum Prevention Program in preventing the development of postpartum depression in pregnant women who are financially disadvantaged. Ages 18-40. Locations in Providence, RI; Woonsocket, RI.

• Safety and Effectiveness of Antidepressant Therapy in Treating Bipolar Type II Major Depression.
  Interventional study. This study will compare the safety and effectiveness of antidepressant therapy versus mood stabilizing therapy in treating people with bipolar type II major depression. Ages 18 and over. Location in Philadelphia, PA.

• Problem-Solving Therapy for People With Major Depression and Chronic Obstructive Pulmonary Disease.
  Interventional study. This study will evaluate the effectiveness of problem-solving therapy combined with treatment adherence procedures in treating older people with major depression and chronic obstructive pulmonary disease. Ages 50-95. Location in White Plains, NY.

• Effectiveness of Cognitive Behavioral Therapy in Reducing Depressive Symptoms in Physically Ill Youth.
  Interventional study. This study will compare the effectiveness of cognitive behavioral therapy with supportive nondirective therapy in reducing emotional distress and improving functioning in youth with inflammatory bowel disease and depression. Ages 9-17. Locations in Boston, MA; Pittsburgh, PA.

• Effectiveness of Parent-Child Interaction and Emotion Development Therapy in Treating Preschool Children With Depression.
  Interventional study. This study will evaluate the effectiveness of parent-child interaction therapy that includes an emotion development component in treating depression in preschool children. Ages 3-6. Location in St. Louis, MO.

• Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder.
  Interventional study. This study will compare the effectiveness of cognitive behavioral therapy versus supportive psychotherapy in decreasing depression in people with bipolar disorder. Ages 18-64. Location in Boston, MA.

• Effectiveness of Behavioral Treatments for Obesity and Major Depression in Women.
  Interventional study. This study will compare the effectiveness of two weight loss programs, one supplemented with health education and the other supplemented with behavioral counseling, in treating women who are depressed and overweight. Ages 21-65. Location in Worcester, MA.

• Effects of Adding Motivational Interviewing to Antidepressant Treatment for Hispanic Adults With Depression.
  Interventional study. This study will evaluate the effectiveness of adding motivational interviewing to antidepressant treatment for major depressive disorder in Hispanic adults. Ages 18-79. Location in New York, NY.

• CBT for Adherence and Depression in Diabetes.
  Interventional study. This study will evaluate the effectiveness of cognitive behavioral therapy (CBT) in treating people with depression and type 2 diabetes. Ages 18-80. Location in Boston, MA.

• Effectiveness of Case Management Versus Case Management Plus Problem-solving Therapy to Treat Depression in Low-income Elders.
  Interventional study. This study will compare the effectiveness of case management combined with problem-solving therapy (CM-PST) versus case management (CM) alone for assisting elderly people with depression. Ages 60-95. Locations in San Francisco, CA; White Plains, NY.

• Evaluating the Effectiveness of Escitalopram to Prevent Depression in Head and Neck Cancer Patients Receiving Treatment.
  Interventional study. This study will evaluate the effectiveness of escitalopram to prevent depression in head and neck cancer patients receiving treatment. Ages 19 and over. Location in Omaha, NE.

• Evaluating a Behavioral Activities Treatment Program for Depressed Nursing Home Residents.
  Interventional study. This study will evaluate whether a behavioral activities treatment program improves symptoms of depression in nursing home residents. Location in Louisville, KY.

• Evaluating the Effects of Stress in Pregnancy.
  Evaluation study. This study will evaluate pregnant women with a past or current diagnosis of depression or anxiety to gain a better understanding of how these disorders can affect an infant's development, both during and after pregnancy. Ages 18-45. Location in Atlanta, GA.

• Pharmacogenomics of Antidepressant Response in Children and Adolescents.
  Evaluation study. This study will identify variations in genes that may be involved in the development of suicidal events or certain behaviors in youth who are exposed to antidepressant medications. Ages 7-17. Location in Durham, NC.

• Omega-3 Fatty Acids for Treating Adults With Major Depression.
  Interventional study. This study will test the effectiveness of two different kinds of omega-3 fatty acid dietary supplements in treating the symptoms of major depression. Ages 18-80. Location in Los Angeles, CA.

• Cognitive Behavioral Therapy to Help HIV Infected Adults With Depression to Adhere to Antiretroviral Therapy.
  Interventional study. This study will compare the effectiveness of a cognitive behavioral intervention versus usual clinic care in helping HIV infected adults with depression to take their HIV medications on schedule. Ages 18-60. Location in Torrance, CA.

• Reducing Health Risk Behavior and Improving Health in Adolescents With Depression.
  Interventional study. This study will determine the effectiveness of a health education intervention in reducing health risk behavior and improving health in adolescents with depression. Ages 13-18. Location in Los Angeles, CA.

• Peer Support for Increasing Physical Activity in People With Serious Mental Illnesses.
  Interventional study. This study will determine the effectiveness of a peer support system in increasing physical activity and effecting health behavior change in people with serious mental illnesses. Ages 18-70. Location in Baltimore, MD.

• Pre-Treatment Positron Emission Topography Scanning for Increasing Success in Antidepressant Treatment.
  Interventional study. This study will use pre-treatment positron emission topography and functional magnetic resonance imaging scans of the brain to predict the most effective antidepressant treatment for people with major depressive disorder. Ages 18-65. Location in New York, NY.

• Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders.
  Evaluation study. This study is intended to help develop new MRI imaging techniques for studying mood and anxiety disorders. Ages 18-50. Location in Bethesda, MD.

• Effects of Interpersonal Psychotherapy on Depression During and After Pregnancy.
  Interventional study. This study will evaluate the impact of interpersonal psychotherapy on the course of depression during and after pregnancy, as well as its effect on infant birth outcomes. Ages 21-45. Location in Ann Arbor, MI.

• The Antidepressant Efficacy of the Anticholinergic Scopolamine.
  Interventional study. A previous study showed that the intravenous administration of scopoalmine produces antidepressant effects. Ages 18-55. Location in Bethesda, MD.

• Supportive Therapy Versus Problem Solving Therapy in Treating Depressed, Cognitively Impaired Older Adults.
  Interventional study. This study will evaluate the effectiveness of problem solving therapy in treating depressed, cognitively impaired older adults. Ages 65 and over. Location in White Plains, NY.

• Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients.
  Interventional study. The primary purpose of this protocol is to compare PDE4 levels before and after starting a selective serotonin reuptake inhibitor (SSRI) sertraline, citalopram or escitalopram in unmedicated depressed patients. Ages 18-55. Location in Bethesda, MD.

• Effectiveness of a Telephone-Delivered Behavioral Treatment to Improve the Quality of Life of Older Adults With HIV.
  Interventional study. This study will evaluate the effectiveness of a telephone-delivered coping improvement group intervention in improving quality of life in older adults with HIV. Ages 50 and over. Location in Athens, OH.

• Identifying Factors That Predict Antidepressant Treatment Response.
  Interventional study. This study will compare different treatments for depression in order to identify which factors predict effectiveness, and will include a companion study which investigates combining treatments and long term effectiveness. Ages 18-65. Location in Atlanta, GA.

• Motivational Interviewing to Improve Medication Adherence Among Hispanic Adults With Depression.
  Interventional study. This study will determine the effectiveness of motivational interviewing in improving antidepressant medication adherence among Hispanics. Ages 18-65. Location in New Brunswick, NJ.

• Interpersonal Psychotherapy for Depression in People With Heart Failure.
  Interventional study. This study will evaluate the effectiveness of interpersonal psychotherapy and behavioral activation techniques in treating depression in people with congestive heart failure. Ages 55 and over. Location in Iowa City, IA.

• Evaluating the Effectiveness of Escitalopram in Preventing or Reducing Depressive Symptoms in People Receiving Interleukin-2 Treatment.
  Interventional study. This study will determine the effectiveness of an antidepressant in preventing or reducing depressive symptoms in people with melanoma who are receiving Interleukin-2 (IL-2) treatment. Ages 18-75. Location in Atlanta, GA.

• Group Intervention for Interpersonal Trauma.
  Interventional study. This study will assess the acceptability and effectiveness of a six-session, modular, repeating group for low-income women who have symptoms of depression and/or post-traumatic stress disorder following interpersonal trauma exposure. Ages 18-70. Location in Washington, DC.

• Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder.
  Interventional study. This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder. Ages 12-17. Location in New York, NY.

• Antidepressant Medication Plus Directly Observed Therapy for Improving Adherence to Antiretroviral Therapy.
  Interventional study. This study will evaluate the effectiveness of directly observed therapy plus antidepressant medication in improving adherence to antiretroviral drug therapy among HIV-infected homeless and marginally housed people with depression. Ages 18 and over. Location in San Francisco, CA.

• Prevention of Depression in Spouses of People With Cognitive Impairment.
  Interventional study. This study evaluates the effectiveness of a problem-solving training program in preventing depression in the spouses or family caregivers of persons with mild cognitive impairment or early dementia. Ages 18 and over. Location in Pittsburgh, PA.

• Identification and Therapy of Postpartum Depression.
  Interventional study. This study will evaluate the effectiveness of a telephone-based depression screening and care management program in treating depression in postpartum women. Ages 18 and over. Location in Pittsburgh, PA.

• Bipolar II Depression: Lithium, SSRI, or the Combination.
  Interventional study. This study will compare the safety and effectiveness of a mood stabilizing medication, an antidepressant medication, and a combination of both medications to treat symptoms of bipolar type II depression. Ages 18-65. Locations in Los Angeles, CA; Palo Alto, CA; Mason, OH.

• Effectiveness of Interpersonal Psychotherapy in Treating Pregnant Women With Depression.
  Interventional study. This study will evaluate the effectiveness of interpersonal psychotherapy in treating pregnant women with depression. Ages 18-47. Location in New York, NY.

• Effectiveness of Culturally Based Congruent Care in Treating Hispanics With Major Depressive Disorder.
  Interventional study. This study will develop and evaluate the effectiveness of a culturally based program that aims to facilitate entry, retention, and successful treatment in specialized mental health services for Hispanics with major depressive disorder. Ages 18-80. Location in New York, NY.

• Understanding Brain Reward Responses in Individuals With Major Depressive Disorder.
  Evaluation study. This study will examine brain responses associated with reinforcement and reward tasks in individuals with major depressive disorder (MDD). Ages 18-64. Locations in Boston, MA; Cambridge, MA; Charlestown, MA.

• Family Cognitive Behavioral Therapy for Preventing Depression in Children.
  Interventional study. This study will determine the effectiveness of cognitive behavioral therapy (CBT) versus educational treatment in preventing depression in the children of parents with a history of depression. Ages 10 and over. Location in Nashville, TN.

• Determining Changes in Brain Structure Associated With Symptoms of Late-Life Depression.
  Evaluation study. This study will determine the changes in brain structure and function that are responsible for mood and cognition changes that are sometimes associated with late-life depression. Ages 55 and over. Location in Pittsburgh, PA.

• Effect of Family-Based Prevention on Children of Depressed Parents.
  Interventional study. This study will test the Protecting Families Program, a 10-week prevention program for depressed parents and their pre-teenage children, by comparing the effectiveness of the program versus parent training alone. Ages 9 and over. Location in Philadelphia, PA.

• A Clinic-Based Prevention Program for Families of Depressed Mothers.
  Interventional study. This study will assess the effectiveness of the "Keeping Families Strong" program (KFS) in avoiding or delaying the onset of psychiatric disorders among children with depressed mothers. Ages 8 and over. Location in Baltimore, MD.

• Parent Psychoeducation and Cognitive Behavior Therapy for Latino Adolescents With Depression.
  Interventional study. This study will determine the effectiveness of adding a parent-involved intervention to cognitive behavior therapy in reducing depressive symptoms among Latino adolescents with depression. Ages 13-17. Location in San Juan, Puerto Rico.

• Hormone and Sleep Response to Antidepressant Treatment in Adolescents and Adults With Depression.
  Interventional study. This study will determine whether there are age-related differences in the body systems controlling sleep and stress hormone patterns. Ages 12-50. Location in Dallas, TX.

• Hormonal Causes of Menstrual-Related Mood Disorders.
  Evaluation study. This study will explore possible hormonal causes of menstrual-related mood disorders (MRMD) by stopping the menstrual cycle with a drug called Lupron and then giving in sequence two menstrual cycle hormones, progesterone and estrogen. Ages 18-50. Location in Bethesda, MD.

• Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood Disorders.
  Evaluation study. This study will investigate how the brain process emotions in healthy people and in patients who have major depression in order to better understand the causes of depression. Ages 18-50. Location in Bethesda, MD.

• Rapid Antidepressant Effects of Ketamine in Major Depression.
  Interventional study. This study examines whether Ketamine can cause a rapid-next day antidepressant effect in patients with Major Depression/Bipolar Disorder . Ages 18-65. Location in Bethesda, MD.

• Function of Catecholamines in the Brain During Depression.
  Evaluation study. This study will explore brain function related to depressive symptoms and will examine DNA for genes that may be involved in depressive disorders, particularly genes that regulate synthesis and metabolism of the brain neurotransmitter catecholamine. Ages 18-45. Location in Bethesda, MD.

• Dutasteride to Treat Women With Menstrually Related Mood Disorders.
  Interventional study. This study will explore the effects of dutasteride on mood and the stress response across the menstrual cycle. Ages 30-50. Location in Bethesda, MD.

• Rapid Antidepressant Effects of Yohimbine in Major Depression.
  Interventional study. This study examines if Yohimbine, when given during the sleep cycle, will improve symptoms of depression within a matter of hours. Ages 18-65. Location in Bethesda, MD.

• The Effects of Estrogen Withdrawal on Mood Symptoms in Women.
  Evaluation study. This study evaluates the effects on mood when stopping estrogen replacement therapy. Ages 45-65. Location in Bethesda, MD.

• Clinical Trial of Estrogen for Postpartum Depression.
  Interventional study. This study evaluates the efficacy of estrogen treatment in women with postpartum depression (PPD). Ages 20-45. Location in Bethesda, MD.

• Screening Evaluation for Women With Postpartum Depression.
  Evaluation study. This study evaluates the relationship between mood changes and hormones in women with postpartum depression (PPD). Ages 20-45. Location in Bethesda, MD.

• Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies.
  Interventional study. This study looks at the role of a specific brain chemical system in the mood and attention symptoms seen in major depression and bipolar disorders using functional brain imaging.... Ages 18-55. Location in Bethesda, MD.

• Raloxifene and Rimostil for Perimenopause-Related Depression.
  Interventional study. The purpose of this study is to evaluate the effectiveness of the drugs raloxifene and rimostil in treating perimenopause-related depression. Ages 40-60. Location in Bethesda, MD.

• Examination of Brain Serotonin Receptors in Patients With Mood Disorders.
  Evaluation study. The purpose of this study is to evaluate the function of certain brain chemicals and receptors in patients with mood disorders. Ages 18-60. Location in Bethesda, MD.

• Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes.
  Evaluation study. This study uses functional magnetic resonance imaging (fMRI) to learn how the brain functions in adolescents receiving fluoxetine (Prozac) cognitive behavioral therapy (CBT) or interpersonal therapy (IPT) for anxiety or depression in children/adolescents. Ages 8-40. Location in Bethesda, MD.

• Combined Hormone Replacement in Menstrually-Related Mood Disorders.
  Evaluation study. This study investigates the effects on symptoms of combined treatment with estrogen and progesterone in women with severe premenstrual syndrome (PMDD). Ages 18-50. Location in Bethesda, MD.

• Perimenopause-Related Mood and Behavioral Disorders.
  Evaluation study. The purpose of this study is to investigate mood and behavior changes in the time period surrounding and including menopause. Ages 40-60. Location in Bethesda, MD.

• A Treatment Study for Premenstrual Syndrome (PMS).
  Evaluation study. This study examines the effects of estrogen and progesterone on mood, the stress response, and brain function and behavior in women with premenstrual syndrome. Ages 18-45. Location in Bethesda, MD.

• Brain Tissue Collection for Neuropathological Studies.
  Evaluation study. The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders. Locations in Washington, DC; Bethesda, MD; Fairfax, VA.

• Evaluation of the Genetics of Bipolar Disorder.
  Evaluation study. This study looks to identify genes that may affect a person's chances of developing bipolar disorder (BP) and related conditions. Ages 18 and over. Location in Bethesda, MD.

• Study of Premenstrual Syndrome and Premenstrual Dysphoria.
  Evaluation study. The purpose of this study is to identify and describe the symptoms of premenstrual syndrome (PMS). Ages 18-50. Location in Bethesda, MD.

• The Role of Hormones in Postpartum Mood Disorders.
  Evaluation study. Determine whether postpartum depression is triggered by the abrupt withdrawal of estrogen and progesterone. Ages 18-40. Location in Bethesda, MD.